Transcranial Doppler During Liver Transplantation

Not Applicable

• Conditions: Liver Transplantation; Neurologic Deficits; Complication, Postoperative; Ultrasonography, Doppler, Transcranial
• Interventions: Diagnostic Test: Transcranial Doppler

• Registration Number: NCT05144451
• Lead Sponsor: Mansoura University

Brief Summary

This is a prospective study that would investigate the transcranial doppler (TCD) changes during the living donor liver transplantation and the association between the TCD changes and the post-transplant neurological complications.

Detailed Description

Objectives:

Participants \& Setting:

Intervention \& Measurements:

Sample size:

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2021-11-22
• Study First Submitted QC: 2021-11-22
• Study Start: 2021-11-28
• Study First Posted: 2021-12-03
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-07
• Last Update Posted: 2022-04-14
• Primary Completion: 2023-11-28
• Study Completion: 2024-04-28

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• all patients scheduled for living donor liver transplantation for whatever the indication at Gastrointestinal surgery center (GISC)

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Exclusion Criteria

• Patients with coexisting neuropsychiatric or cerebrovascular disorders or those who have a history of head trauma or brain surgery

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
TCD arm	Transcranial Doppler	All patients will be evaluated with TCD for prediction of the post-transplant neurological complications

Primary Outcome Measures

Name	Time	Method
Post-transplant Neurological Complication	28 days after transplantation	incidence of Neurological Complication as a composite outcome (tremors, seizures, demyelination, posterior reversible encephalopathy syndrome, stroke)

Secondary Outcome Measures

Name	Time	Method
flow patterns throughout the transplant surgery and in the ICU	intraoperative and 7 days after transplantion	normal, hyperemic, low-flow, or vasospastic flow by TCD

Trial Locations

Locations (1)

Mansoura University, Gastrointestinal Surgery Center, Liver Transplantation Unit; 🇪🇬 Mansoura, Dakahlia, Egypt