Association of Functional Changes in the Brain and the Perception of Pain in Patients With Chronic Inflammatory Bowel Diseases (IBD)
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Inflammatory Bowel Disease
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Changes in perception of pain measured with visual analogue scale and pain pressure threshold
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
In the study the investigators aim to test whether transcranial direct current stimulation (tDCS)-induced pain reduction is in association with functional changes in the brain measured with magnetic resonance imaging (MRI) in patients with chronic inflammatory bowel diseases (IBD).
Hypothesis: Transcranial direct current stimulation can reduce the perception of pain in patients with chronic inflammatory bowel diseases, which is in association with changes in the brain measured via MRI.
Investigators
Magdalena S. Prüß née Volz
Dr. med. Magdalena Sarah Prüß (geb. Volz)
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •Inflammatory bowel disease
- •Chronic pain (more than 3 months)
- •Pain (VAS \> 3/10)
Exclusion Criteria
- •Contraindication to transcranial direct current stimulation
- •Contraindications to magnetic resonance imaging (MRI)
- •Pregnancy
- •Sever internal or psychiatric condition
Outcomes
Primary Outcomes
Changes in perception of pain measured with visual analogue scale and pain pressure threshold
Time Frame: 2 weeks
Participants will be followed for 2 weeks
Functional and/or structural changes in the brain measured with cerebral MRI
Time Frame: 1 week
Participants will be followed for 2 weeks
Secondary Outcomes
- Changes in activity indices (Harvey-Bradshaw Index (HBI) or simple clinical colitis activity index)(2 weeks)
- Changes in quality of life(2 weeks)
- Changes in pain catastophizing scale(2 weeks)
- Changes in inflammation bBlood)(2 weeks)
- Changes in functional symptoms (questionnaire: Irritable bowel syndrome - severity scoring system (IBS-SSS))(2 weeks)
- Changes in inflammation (stool - calprotectin)(2 weeks)