Effect of Aerobic Exercise in Patients With Essential Hypertension

Completed

• Conditions: Aerobic Exercise; Essential Hypertension

• Registration Number: NCT05987436
• Lead Sponsor: TC Erciyes University

Brief Summary

The goal of this observational study is to evaluate the effects of a supervised aerobic exercise training program on weight loss, functional capacity, quality of life (QoL), and depression levels in patients with essential hypertension.

Detailed Description

Patients who chose the treatment type according to personal preferences were divided into two groups: Group 1(n:91) exercised for six weeks, five sessions per week under the supervision of a medical doctor in the aerobic exercise laboratory, and group 2(n:47) was advised to maintain dietary habits and physical activity levels. Body weight, serum lipid levels, functional capacity, QoL, and depression level of all the participants were evaluated at baseline and 6 weeks later.

Study Timeline

• Study Start: 2017-11-01
• Primary Completion: 2019-04-01
• Study Completion: 2019-12-01
• Study First Submitted: 2023-07-25
• Status Verified: 2023-08
• Study First Submitted QC: 2023-08-03
• Last Update Submitted: 2023-08-03
• Study First Posted: 2023-08-14
• Last Update Posted: 2023-08-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 138

Inclusion Criteria

• Over 18 years of age,
• Absence of concomitant other metabolic and cardiovascular diseases.

Exclusion Criteria

• Having suffered an event of ischaemic heart disease (<6 months),
• Secondary hypertension,
• Hypertrophic obstructive cardiomyopathy,
• Congestive heart failure,
• Uncontrolled cardiac arrhythmia,
• Thyroid dysfunction,
• Diabetes mellitus,
• Symptomatic peripheral arterial occlusive disease,
• Aortic insufficiency or stenosis,
• Pulmonary or heart disease with dyspnoea at small or moderate effort,
• An outbreak of orthopedic problems on hip, knee or ankles, such as arthroplasty, contracture or severe osteoarthritis,
• Using of antidepressant or anxiolytic drugs,
• Pregnancy,
• Cognitive disfunction.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The functional capacity	6MWT was assessed in face-to-face interviews before and immediately after the treatment was completed.	The 6MWT test and the estimated metabolic equivalents or METs were used performed to evaluate functional capacity.
Body weight	was measured at the pre-treatment period and the post-treatment 6th week for all the participants by the same physician.	kilograms
Quality of Life	SF36 was assessed in face-to-face interviews before and immediately after the treatment was completed.	Quality of life was assessed with Short Form-36 (SF-36).
Depression level	BDI was assessed in face-to-face interviews before and immediately after the treatment was completed.	Depression level was assessed Beck Depression Inventory (BDI).
Blood samples	Twelve-hour fasting blood samples were collected between 6.00 am, and 10.00 am at baseline and week 6.	Serum total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol, and triglycerides

Trial Locations

Locations (1)

Selcuk University Faculty of Medicine; 🇹🇷 Konya, Turkey