A Spontaneous Breathing Trial-based Protocol-directed Program in Difficult-to-Wean Patients

JinyanXing1 site in 1 country200 target enrollmentJanuary 1, 2019

ConditionsRespiration, Artificial

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Respiration, Artificial
Sponsor: JinyanXing
Enrollment: 200
Locations: 1
Primary Endpoint: mechanical ventilation days
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Weaning patients from a ventilator is one of the most challenging processes in an intensive care unit. The investigators aimed to determine whether spontaneous breathing trial (SBT)-based protocol-directed weaning combined with the high-flow nasal cannula (HFNC) could be superior to routine SBT-based weaning in reducing the duration of mechanical ventilation (MV) in difficult-to-wean patients.

Registry

clinicaltrials.gov

Start Date

January 1, 2019

End Date

December 31, 2021

Last Updated

4 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

JinyanXing

Responsible Party

Sponsor Investigator

Principal Investigator

JinyanXing

Director

The Affiliated Hospital of Qingdao University

Eligibility Criteria

Inclusion Criteria

•age ≥ 16 years old
•MV for more than 48 hours
•intubated or tracheostomized

Exclusion Criteria

•pregnancy
•irreversible respiratory failure caused by neurodegenerative disorders, such as Alzheimer disease, motor neuron disease, or multiple system atrophy
•pre-existing decision to limit life support
•waiving of MV during treatment
•terminal stage of severe illness