A SBT-based Protocol-directed Program in Difficult-to-Wean Patients

Not Applicable

• Conditions: Respiration, Artificial

• Registration Number: NCT05035355
• Lead Sponsor: JinyanXing

Brief Summary

Weaning patients from a ventilator is one of the most challenging processes in an intensive care unit. The investigators aimed to determine whether spontaneous breathing trial (SBT)-based protocol-directed weaning combined with the high-flow nasal cannula (HFNC) could be superior to routine SBT-based weaning in reducing the duration of mechanical ventilation (MV) in difficult-to-wean patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-01
• Study First Submitted: 2021-08-30
• Study First Submitted QC: 2021-08-30
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-03
• Study First Posted: 2021-09-05
• Last Update Posted: 2021-09-10
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• age ≥ 16 years old
• MV for more than 48 hours
• intubated or tracheostomized

Exclusion Criteria

• pregnancy
• irreversible respiratory failure caused by neurodegenerative disorders, such as Alzheimer disease, motor neuron disease, or multiple system atrophy
• pre-existing decision to limit life support
• waiving of MV during treatment
• terminal stage of severe illness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
mechanical ventilation days	60 days	the duration of mechanical ventilation

Secondary Outcome Measures

Name	Time	Method
re-intubated within 24 hours	24 hours	re-intubated within 24 hours

Trial Locations

Locations (1)

The Affiliated Hospital of Qingdao University; 🇨🇳 Qingdao, Shandong, China