Isolation of Volatile Organic Compounds (VOCs) Related to the Olfactory Signature of Breast Cancer

Not Applicable

Completed

Brief Summary: To ascertain the possibilities to isolate the breast cancer olfactive signature.

Detailed Description: Patient recruitment during the first surgery consultation in Curie Institute. Odor sampling (non-invasive) with an odor-sensing polymer (Sorbstar® polymer developed especially for the trace level analysis), on:

* The hands, before and after surgical excision of the tumor (friction of the hands)

* The diseased breast, before and after surgical excision of the tumor (via a compress positioned on the breast for 1 night)

* The tumor, during the surgical procedure (odor collection over a tumor sample).

Each patient will be her own witness, before and after surgical excision, in an attempt to isolate the chemical signature tracks of breast cancer. The samples after surgery will be made after healing and before implementation of a treatment (chemotherapy and / or radiotherapy).

Recruitment & Eligibility

Inclusion Criteria

Patient received in surgery consultation for an invasive non metastatic breast cancer treated by breast-conserving surgery with axillary or sentinel node dissection
Of-Age female patient (over 18 years old)
Life expectancy > to 1 year at the inclusion
Performance status: 0 or 1 or 2
Patient benefiting from the social security
Signature informed consent of the study

Exclusion Criteria

Neoplasia in progress or neoplasia history of cancer other than breast to be treated.
Wound presence on breasts
Male subjects
Specified metastatic breast cancer
Concomitant medication taken one month before the surgical act (antibiotics, corticoids, anti-diabetics)
Persons under guardianship or deprived of liberty
Impossibility to submit to the medical monitoring expected by the study for geographical, social or psychological reasons.

Arm && Interventions

Group	Intervention	Description
Sorbstar®	Sorbstar®	Odour sampling: Rub hands with Sorbstar® before and post-surgery
Dog detection	Odour sampling	Odour sampling: Sleep over a night with a compress on the affected breast before and after surgery

Primary Outcome Measures

Name	Time	Method
Ascertain breast cancer olfactive signature (Isolation of volatile Organic Compounds to breast cancer by a sensitive technique with an odor-sensing polymer (Sorbstar®)	12 months	Isolation of volatile Organic Compounds to breast cancer by a sensitive technique with an odor-sensing polymer (Sorbstar®) on hands. Friction of the hands according to the protocol before and after surgical excision of the tumor. Sorbstar® analyses will be performed with a thermodesorption method coupled with full two-dimensional gas chromatography and mass spectrometry.

Secondary Outcome Measures

Name	Time	Method
Ascertain breast cancer detection by the dogs of Curie Institut	13 months	Patients sleep over a night with a compress positioned on the affected breast before and after surgery. The compress will be analyzed by the dogs of Curie Institut (results cancer/not cancer).
Ascertain breast cancer olfactive signature from the tumor (Isolation of volatile Organic Compounds to tumor breast samples by a sensitive technique with an odor-sensing polymer (Sorbstar®).	13 months	During the surgical procedure an odor-sensing polymer (Sorbstar®) over the tumor is placed. Sorbstar® analyzes will be performed with a thermodesorption method coupled with full two-dimensional gas chromatography and mass spectrometry.

Receive instant email notifications about changes in this clinical trial

Receive instant email notifications about changes in this clinical trial