Risk Factors for Intensive Care Admission of Children With Severe Acute Wheeze or Asthma (SAA)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 221
- 试验地点
- 1
- 主要终点
- Undertreatment in children admitted to a PICU with a diagnosis of SAA/acute wheeze
研究概览
简要总结
This study will prospectively assess the impact and relevance of several risk factors for children with severe acute asthma (SAA) or acute wheeze that have been identified in retrospective studies. Secondary we will assess short-term medical and psychosocial functioning in patient (and parents) admitted to a PICU for SAA/acute wheeze versus a control group admitted to a MC for SAA/acute wheeze.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Between 2 and 18 years of age
- •Admission to a PICU for SAA or acute wheeze or admission to a MC for SAA or acute wheeze
排除标准
- •Patient is outside of specified age range
- •Down's Syndrome
- •Congenital/acquired heart defect that interferes with normal SAA treatment
- •Congenital/acquired airway defect (tracheomalacia/bronchomalacia)
- •Primary/secondary immunodeficiency
- •Pre-existing chronic pulmonary condition, known to mimic asthma: Cystic Fibrosis, Bronchopulmonary dysplasia, Bronchiolitis obliterans
- •If both parents are not able to speak the Dutch language
结局指标
主要结局
Undertreatment in children admitted to a PICU with a diagnosis of SAA/acute wheeze
时间窗: Within the time of admission on the PICU/MC, preferably within 48 hours and during follow up after 3-6 months
Undertreatment is defined as: Patient is not using inhaled corticosteroids (ICS), or Patient is using ICS \< 7 days (counting from moment of admission to emergency department) according to treatment plan, or Patient is not using ICS according tot treatment plan.
次要结局
- Exposure to triggers (single or combined)(Within the time of admission on the PICU/MC, preferably within 24 hours)
- Severity of disease, defined using the GINA criteria for stepwise management of asthma.(Within the time of admission on the PICU/MC, preferably within 48 hours and during follow up after 3-6 months)
- Distribution of ADRB2-receptor polymorphisms compared to non-SAA population.(Through study completion, preferably within the time of admission on the PICU/MC)
- Socio-economic status(Within the time of admission on the PICU/MC)
- Frequency of previous asthma-related hospital admissions and/or PICU admissions.(Within the time of admission on the PICU/MC and during follow up after 3-6 months)
研究者
Matthijs de Hoog
Prof. Dr.
Erasmus Medical Center