A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery - ALLEGRO

The University Of Edinburgh0 个研究点目标入组 748 人开始时间: 2018年1月24日最近更新: 2019年6月30日

适应症

试验速览

暂无简介。

•Patients scheduled for elective colorectal resection for colorectal cancer or diverticular disease at participating UK colorectal surgery units.
•Right hemicolectomy, extended right hemicolectomy, left colectomy, sigmoid colectomy, subtotal colectomy with ileosigmoid or ileorectal anastomosis and high anterior resection are eligible
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 187
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 561

•Planned epidural anaesthesia
•Planned regional or local infiltration of lidocaine at the same time as lidocaine infusion
•Current pregnancy or breast feeding
•Age <18 years
•Patients lacking capacity to give informed consent.
•Known or suspected allergy to lidocaine or amide-type local anaesthetics
•Current complete heart block
•Current severe liver dysfunction (Child’s A or greater)
•Current renal failure (eGFR<30)
•Patients participating in the active intervention phase of another therapeutic clinical trial (or other interventional trial) unless a co-enrollment agreement is in place
•Patients having surgery for indications other than colorectal cancer/diverticular disease
•Rectal cancer below the peritoneal reflection in which total mesorectal excision is anticipated
•Rectal cancer patients who have received any neoadjuvant radiotherapy
•A preoperative surgical plan to form any new stoma during the primary procedure

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