A randomized, controlled trial of early versus late initiation of peritoneal dialysis
Not Applicable
- Conditions
- end stage renal disease patientsESRDinitiation of dialysisPeritoneal dialysisglomerular filtration rate
- Registration Number
- TCTR20140814001
- Lead Sponsor
- Health System Research Institute (HSRI), Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
1 CKD stage 5 patients with GFR 9 ml min 1 73m2
2 age 20 years and willing to participate in this study
3 under optimal care by nephrologist at least 2 months before initiation of peritoneal dialysis
4 under NHSO National health security office Thailand coverage
Exclusion Criteria
1 planned living related kidney transplantation
2 cancer disease with expected survival time less than 3 years
3 patients with indication for emergency dialysis including uremia pulmonary edema dyspnea resistant hypertension significant acidemia hyperkalemia unresponse to medical treatment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method survival rate 3 years after initiation of dialysis survival rate
- Secondary Outcome Measures
Name Time Method 1.Disease complications 3 years after initiation of dialysis a.Myocardial infarction b.Cerebrovascular event c.Infection,2.Dialysis complications 2 years after initiation of dialysis a.PD-related Peritonitis, exit site infection/tunnel infection b.Non-infectious complication c.Em,3.Quality of life every 6 months assess by EQ-5D-5L,4.Hospitalization every 6 months time to first hospitalization, total admission day,5.Residual renal function every 6 months rate of decline,6.Technique survival every 6 months dialysis mode,7.Nutritional assessment every 6 months malnutrition inflammation score,8.Economic evaluation every 6 months direct and indirect cost