ADEPT - Abnormal Doppler Enteral Prescription Trial

Completed

• Conditions: utrition; Neonatal Diseases

• Registration Number: ISRCTN87351483
• Lead Sponsor: niversity of Oxford (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2004-09-30
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

Infants admitted to participating neonatal units and satisfying all of the following criteria may be recruited into the study:
1. Gestational age up to and including 34 weeks + 6 days
2. Antenatal ultrasound showing either:
2.1. Absent or reversed end diastolic flow velocities on at least 50% of the Doppler waveforms from the umbilical artery on at least one occasion during pregnancy, or
2.2. Cerebral redistribution, defined as occurring when both the umbilical artery pulsatility index is greater than the 95th centile and the middle cerebral artery pulsatility index is less that the 5th centile for gestational age
3. Small for gestational age
4. Postnatal age 20 - 48 hours

Exclusion Criteria

Infants will be excluded if any of the following factors are present:
1. Major congenital abnormality including known chromosomal abnormality
2. Twin-twin transfusion
3. Intra-uterine transfusion or exchange transfusion
4. Rhesus iso-immunisation
5. Significant multi-organ failure prior to trial entry
6. Inotropic drug support prior to trial entry
7. Already received any enteral feeding

Study & Design

• Study Type: Interventional
• Study Design: Not specified