Study of Subjective Perception of Motor Control During Psychogenic Disorders : Brain Mechanisms and Functional Imaging.
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Familiarization with the joystick.
研究概览
简要总结
The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder.
The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin.
Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.
详细描述
New results will be provided about brain mechanisms involved in motor control perception among healthy patients and patients suffering from functional neurologic symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed informed consent
- •Medical exam médical done before study participation
- •Between 18 and 65 years
- •Right-handed persons
- •Conversion disorder based on DSM IV-R criterias
- •Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking)
排除标准
- •Subjects included in a clinical and/or therapeutic exeprimentation in progress
- •People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia
- •Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale
- •History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding.
- •Alcohol ingestion
- •Pregnant, parturient or breastfeeding women
- •All other categories of protected persons
结局指标
主要结局
Familiarization with the joystick.
时间窗: 30 minutes
HHSC-JOY-I from Current Designs. They are asked to trace a straight line.
Brain MRI
时间窗: One hour and a half
次要结局
未报告次要终点