Subjective Perception of Motor Control During Psychogenic Disorders

Not Applicable

Terminated

• Conditions: Somatoform Disorders
• Interventions: Other: functional brain MRI

• Registration Number: NCT02843932
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder.

The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin.

Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.

Detailed Description

New results will be provided about brain mechanisms involved in motor control perception among healthy patients and patients suffering from functional neurologic symptoms.

Study Timeline

• Study First Submitted: 2015-05-12
• Study Start: 2015-05-13
• Study First Submitted QC: 2016-07-22
• Study First Posted: 2016-07-26
• Primary Completion: 2019-06
• Study Completion: 2019-06
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-16
• Last Update Posted: 2020-11-18

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Signed informed consent
• Medical exam médical done before study participation
• Between 18 and 65 years
• Right-handed persons
• Conversion disorder based on DSM IV-R criterias
• Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking)

Exclusion Criteria

• Subjects included in a clinical and/or therapeutic exeprimentation in progress
• People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia
• Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale
• History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding.
• Alcohol ingestion
• Pregnant, parturient or breastfeeding women
• All other categories of protected persons

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Psychogenic disorders	functional brain MRI	Psychogenic movement disorders and seizures

Primary Outcome Measures

Name	Time	Method
Familiarization with the joystick.	30 minutes	HHSC-JOY-I from Current Designs. They are asked to trace a straight line.
Brain MRI	One hour and a half

Trial Locations

Locations (1)

Chu Grenoble; 🇫🇷 Grenoble, France