Randomized phaseII study of S-1 and concurrent radiotherapy with versus without induction chemotherapy for locally advanced pancreatic cancer. (JCOG1106)
Phase 2
- Conditions
- locally advanced pancreatic cancer
- Registration Number
- JPRN-UMIN000006811
- Lead Sponsor
- Japan Clinical Oncology Group (JCOG)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1) Interstitial pneumonia or fibroid lung 2) Watery diarrhea 3) Severe complication, such as heart disease, renal disease, and hepatic disease 4) Patients requiring the administration of flucytosine, phenytoin or warfarin potassium 5) Simultaneous or metachronous (within 5 years) double cancers, with the exception of intramucosal tumor curable with local therapy 6) Active infection requiring systemic therapy 7) Fever over 38 degrees Celsius 8) Pregnant or lactating women or women of childbearing potential and men who want to get partner pregnant 9) Psychosis 10) Patients requiring systemic steroids medication 11) Patients who can' t receive neither iodic drug nor gadolinium because of drug allergy "
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method overall survival
- Secondary Outcome Measures
Name Time Method CA19-9 response, distant metastasis-free survival, progression-free survival, adverse events, delayed toxicity, treatment-related death, early death, grade 4 non-hematological toxicity