Effect of synbiotic supplementation in ankylosing spondylitis
Not Applicable
Recruiting
- Conditions
- Ankylosing spondylitis.Ankylosing spondylitis
- Registration Number
- IRCT20190917044794N1
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
Willing to participate
Age range 20-60 years
AS diagnosis by rheumatologist
Exclusion Criteria
Taking nutritional and antioxidant supplements one month prior to study
Pregnancy and lactation
History of other autoimmune diseases
History of diabetes mellitus, IBD
Gastrointestinal infection and other chronic diseases
The recurrence of the disease during the study
Unwilling to continue the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Disease activity. Timepoint: Before and after intervention. Method of measurement: BASDAI and BASFI criteria.;Th17 cells frequency. Timepoint: Before and after intervention. Method of measurement: Flow cytometry.;IL-23/IL-17 axis expression. Timepoint: Before and after intervention. Method of measurement: Real-time PCR and ELISA.;Serum IL-17 cytokine. Timepoint: Before and after intervention. Method of measurement: ELISA kit.;Serum IL-23 cytokine. Timepoint: Before and after intervention. Method of measurement: ELISA kit.
- Secondary Outcome Measures
Name Time Method