The research about the effect of Magnesium Sulfate on vascular endothelial dysfunction, inflammation and oxidative stress in severe preeclampsia.
Not Applicable
- Conditions
- preeclampsia
- Registration Number
- JPRN-UMIN000013891
- Lead Sponsor
- Kyoto University Graduate School of medicine Obstetrics and Gynecology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
The patients who are suffered from myasthenia gravis, cardiac block and hypotonic dehydration which are contraindication for Magnesium Sulfate should be excluded.
Study & Design
- Study Type
- Interventional,observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Maternal serum soluble fms-like tyrosine kinase 1 Maternal serum Tumor Necrosis Factor 1 Maternal urine F2-Isoprostanes
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How does magnesium sulfate modulate vascular endothelial dysfunction and oxidative stress in severe preeclampsia via NOS and eNOS pathways?
What is the comparative effectiveness of magnesium sulfate versus standard antihypertensives in reducing maternal and fetal complications in severe preeclampsia?
Which biomarkers (e.g., sICAM-1, TNF-α) predict response to magnesium sulfate in JPRN-UMIN000013891 severe preeclampsia study?
What are the known adverse events of magnesium sulfate in severe preeclampsia and how are they managed clinically?
How do combination therapies involving magnesium sulfate and antioxidants compare to monotherapy in treating severe preeclampsia's vascular and inflammatory effects?