Etiology of Lymphopenia in Covid19 Infection

Completed

• Conditions: Lymphopenia
• Interventions: Diagnostic Test: Complete blood picture, bone marrow aspiration cytology

• Registration Number: NCT04404608
• Lead Sponsor: Dr Medhat Khafagy

Brief Summary

Study of the cause of lymphopenia in Covid19 viral infection will be done in 3 cohorts. First cohort will be patients asymptomatic or with mild symptoms. Second cohort will be patients with severe illness and admitted to ICU. Third cohort will be patients critically ill and on artificial ventilation.

Detailed Description

Each cohort will include 30 patients. Complete blood count in all patients will be done daily in all patients. Bone marrow aspiration cytology will be done in some selected patients especially those with lymphopenia less than 1000 per cubic mm.

Correlation of the degree of lymphopenia with the status of the patients will be done. Also correlation will be done about the relation of recovery of lymphopenia and status of the patients.

Study Timeline

• Study First Submitted: 2020-05-23
• Study First Submitted QC: 2020-05-26
• Study First Posted: 2020-05-27
• Study Start: 2020-06-01
• Primary Completion: 2021-06-01
• Study Completion: 2021-12-01
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-19
• Last Update Posted: 2022-07-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 172

Inclusion Criteria

• Any patient admitted with the diagnosis of Covid19 viral infection

Exclusion Criteria

• Any patient who died within one day of admission

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Asymptomatic or mild symptoms patients patients	Complete blood picture, bone marrow aspiration cytology	Patients with no or mild symptoms and need no respiratory support.
Severe symptoms patients	Complete blood picture, bone marrow aspiration cytology	Patients who need admission to ICU because he needs oxygen by nasal canula and needs drugs whether azthromycin or remdesivir according to treatment protocol.
Critically ill patients	Complete blood picture, bone marrow aspiration cytology	Patients who need artificial ventilation because of many causes and may need plasma from convalescent patients

Primary Outcome Measures

Name	Time	Method
Death or recovery	Up to 24 weeks	Follow up

Trial Locations

Locations (1)

National Cancer Institute Cairo University; 🇪🇬 Cairo, Egypt