Assessment of the usefulness of plasma copeptin for diagnosing and predicting postoperative central diabetes insipidus
Not Applicable
Recruiting
- Conditions
- Endocrine, nutritional and metabolic diseases
- Registration Number
- KCT0006488
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
? 19 years old or older and less than 80 years old
? Patients under follow-up at the Department of Endocrinology and Metabolism or Neurosurgery at Seoul National University Hospital who have had or are scheduled to undergo pituitary surgery
? Subjects who consent to donation of human material
Exclusion Criteria
? Renal-urinary structural disease
? Uncontrolled diabetes mellitus (HbA1C >8.5% within the last 3 months)
? Taking medications that affect the amount of urine (diuretics, SGLT-2 inhibitors, lithium, etc.)
? Patients with nephrogenic diabetes insipidus
? Patients with suspected primary polydipsia
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differentiation and predictive ability of copeptin concentration and change patterns measured before and after pituitary surgery for transient diabetes insipidus, permanent diabetes insipidus, and triphasic diabetes insipidus
- Secondary Outcome Measures
Name Time Method Predictive ability of copeptin concentration measured after pituitary surgery for diabetes insipidus ;The ability to differentiate between excessive fluid supply and diabetes insipidus of copeptin concentration in the occurrence of hypotonic polyuria after pituitary surgery;Differentiation between ACTH/steroid deficiency and diabetes insipidus in postoperative polyuria in copeptin concentration