A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251
- Registration Number
- NCT05626114
- Lead Sponsor
- Genentech, Inc.
- Brief Summary
This study will evaluate the success and safety of subretinal surgical delivery as well as the preliminary activity of OpRegen in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). All endpoints are assessed for the study eye unless otherwise indicated.
The substudy will evaluate the operational feasibility and scientific interpretability of incorporating AO retinal imaging using the EarlySight Cellularis® Discovery device. Participants who have fulfilled the eligibility requirements for the parent study and meet the substudy's eligibility criteria will have the option to participate in the substudy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
- Ability to undergo a vitreoretinal surgical procedure under monitored anesthesia care
- Diagnosis of GA secondary to AMD
- BCVA score ≥ 29 letters and ≤ 60 letters in the study eye as assessed by Early Treatment Diabetic Retinopathy Study (ETDRS)
- Pseudophakic (study eye)
- Pregnancy or breastfeeding
- History of cognitive impairment or dementia
- Any type of systemic disease or its treatment, in the opinion of the investigator, including any medical conditions that could be expected to progress, recur, or change to such an extent that it may bias the assessment of the clinical status of the participant to a significant degree or put the participant at special risk
Ocular Exclusion Criteria for Study Eye:
- Any current or history of ocular disease other than GA that may confound assessment of the macula
- History of retinal detachment
- History of vitrectomy, glaucoma-filtering surgery, or corneal transplant
- Uncontrolled glaucoma or advanced glaucoma
- Any cataract surgery or intraocular surgery within 3 months prior to subretinal surgical delivery of OpRegen
- History of other ocular or intraocular conditions that contraindicate the use of an investigational drug or may affect interpretation of the study results or may render the participant at high risk for treatment complications
- Any existing posterior segment device or implant
Substudy:
Inclusion Criteria:
- Participants must meet all of the inclusion criteria described in the parent study GR44251 and have the ability to comply with the substudy protocol
Exclusion Criteria:
- Participants who meet any exclusion criteria listed in the parent study GR44251
- Past history of seizures, or epileptic seizures due to any cause except for a single febrile seizure in childhood
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description OpRegen OpRegen OpRegen dose up to approximately 200,000 cells will be delivered into the subretinal space
- Primary Outcome Measures
Name Time Method Proportion of Participants With Subretinal Surgical Delivery of OpRegen to Target Regions 3 months post-surgery Incidence and Severity of Procedure-related Adverse Events (AEs) at 3 Months Following Surgery 3 months post-surgery
- Secondary Outcome Measures
Name Time Method Proportion of Participants With Qualitative Improvement in Retinal Structure, as Determined by Optical Coherence Tomography (OCT) Imaging Within 3 Months Following Surgery 3 months post-surgery
Trial Locations
- Locations (11)
The Retina Institute
🇺🇸Saint Louis, Missouri, United States
Tennessee Retina PC
🇺🇸Nashville, Tennessee, United States
Retina-Vitreous Associates Medical Group
🇺🇸Beverly Hills, California, United States
Retinal Consultants Medical Group
🇺🇸Sacramento, California, United States
West Coast Retina
🇺🇸San Francisco, California, United States
Cincinnati Eye Institute
🇺🇸Blue Ash, Ohio, United States
Mid Atlantic Retina
🇺🇸Philadelphia, Pennsylvania, United States
Austin Clinical Research, LLC
🇺🇸Austin, Texas, United States
Piedmont Eye Center
🇺🇸Lynchburg, Virginia, United States
Hadassah MC
🇮🇱Jerusalem, Israel
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