Basic Auditory Processing and Auditory Hallucinations

Not Applicable

Completed

• Conditions: Schizophrenia
• Interventions: Other: Clinical and psychoacoustic measures

• Registration Number: NCT02887794
• Lead Sponsor: Hôpital le Vinatier

Brief Summary

Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population worldwide. Although pathophysiology of this disease remains unclear, a growing interest is emerging for low-level sensory function, acknowledging that deficits in early stages of sensory processing are related to higher-order cognitive disturbances in schizophrenia. In the field of auditory processing, symptoms as auditory-hallucinations were found correlated with disabilities to discriminate psychoacoustic parameters of sounds.

Detailed Description

Outcomes: Our main hypothesis is that Auditory Hallucinations Rating Scale (AHRS) scores are correlated with the percentage of wrong answers in a Tone-Matching Task test. The main objective is to assess this correlation. Our other objectives are to assess correlation between AHRS as well as other symptoms scales and psychoacoustic tests assessing intensity, length discrimination of non-verbal tones and self-monitoring abilities. Impact of therapeutic procedures (neuromodulation, psychotherapy) conducted independently of our study on these psychoacoustic tests will also be assessed.

Methods: 30 subjects with schizophrenia will be included. Clinical and psychoacoustic measures will be carried out at J-0. In the case of patients receiving therapeutic procedures independently of our study, new clinical and psychoacoustic measures will be carried out at J+7 and J+30.

Study Timeline

• Study First Submitted: 2016-08-03
• Study First Submitted QC: 2016-08-29
• Study First Posted: 2016-09-02
• Study Start: 2016-10-06
• Primary Completion: 2021-06-30
• Study Completion: 2021-07-31
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-11
• Last Update Posted: 2022-08-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

• Age from 18 to 65 years old
• Meeting DSM-5.0 criteria for schizophrenia
• Auditory Hallucinations Rating Scale ≥ 8
• Negative βHCG level if woman
• Effective contraception if woman
• Consent to be included in the study

Exclusion Criteria

• Hearing impairment
• Neurologic disorder
• Other psychiatric disorder from the DSM-5.0 section II
• Developed musical abilities (regular practice of singing or a musical instrument)
• Pregnancy
• Does not consent to be included in the study
• Lacking in legal capacity

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
30 patients with schizophrenia	Clinical and psychoacoustic measures	Measure the correlation between the score on the scale psychometric AHRS (Auditory Hallucination Rating Scale) to measure HAV and performance scores discrimination test psychoacoustic Tone Matching Task in subjects suffering from schizophrenia and HAV.

Primary Outcome Measures

Name	Time	Method
percentage error in discrimination test psychoacoustic Tone Matching Task	immediately after treatment	Our main hypothesis is that Auditory Hallucinations Rating Scale (AHRS) scores are correlated with the percentage of wrong answers in a Tone-Matching Task test.

Secondary Outcome Measures

Name	Time	Method
Score the item hallucinations of psychometric ( positive and negative syndrome ) scale	immediately after treatment	Rating Scale(AHRS) as well as other symptoms scales and psychoacoustic tests assessing intensity, length discrimination of non-verbal tones and self-monitoring abilities.

Trial Locations

Locations (1)

Ch Le Vinatier; 🇫🇷 Lyon, Rhone Alpes, France