Brain metabolic changes during awake and asleep craniotomy measured by cortical microdialysis

Completed

• Conditions: Brain Metabolism; 10029211; 10042258; 10009720

• Registration Number: NL-OMON33779
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Indication for awake craniotomy (asleep-awake-asleep-procedure) or asleep craniotomy
Age 18-80 years
Informed consent

Exclusion Criteria

Diabetes mellitus
Anemia (Hb < 5 mmol/l)
Technical impossibility to place one catheter during the craniotomy.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in brain metabolites (glucose, glycerol, lactate, pyruvate, glutamate)<br /><br>Correlation between depth of anesthesia and brain metabolite changes</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Difference in concentrations of metabolites between radiologically normal<br /><br>tissue and abnormal brain tissue.<br /><br>Brain propofol concentration in the three stages (anesthesia-awake-anesthesia)<br /><br>Blood concentration of metabolites and propofol over time</p><br>