Metabolism and brain circuitry dynamics during trauma exposure therapy with eye movement desensitization and reprocessing (EMDR) versus ego state therapy (EST) in patients with major depressive disorder and traumatic/violence experiences

Not Applicable

Recruiting

Conditions: F33
Recurrent depressive disorder

Registration Number: DRKS00032102

Lead Sponsor: niversitätsklinikum Aachen, RWTH Universität Aachen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

Diagnosis of major depressive disorder (based on DSM-V criteria)
-Additionally post-traumatic stress disorder (PTSD), complex PTSD and/or childhood adversity as comorbidity or precedent factor
-Written consent after comprehensive study information

Exclusion Criteria

-Current substance abuse disorder, schizophrenic disorder, or psychotic depression
-Actual suicidality (scores of 4 or 5 in C-SSRS scale)
-Cardial instability
-Contraindications to MRI, e.g., cardiac pacemaker or ferromagnetic implants
-Contraindications to EMDR or EST therapy, such as lack of stability and real world conflicts in the present
-Individuals who have started psychotherapy in the last three months
-Pregnancy and nursing period

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
clinical symptoms of depression measured by MADRS and BDI-II, baseline versus follow-up after 6, 12 and 14 therapy hours

Secondary Outcome Measures

Name	Time	Method
-agression (BPAQ, OAS-M, STAXI, LHAS), baseline versus follow-up after 6, 12 and 14 therapy hours<br>-emotion regulation (SRQ, CERQ), baseline versus follow-up after 6, 12 and 14 therapy hours<br>-trauma (CAPS-5)<br>-dysregulation within and between neuronal networks (affective network, salience network, cognitive control network, attention networks) and overexpression of VOCs (e.g. TMA, aceton, butyric acid lactate and others related to energy metabolism, short chain fatty acids, tryptophan metabolism), baseline versus follow-up 14 therapy hours