Induction of Ovulation Using Clomiphene Citrate and N-acetyl Cysteine Versus Letrozole

Phase 3

Completed

• Conditions: Infertility
• Interventions: Drug: Letrozole; Drug: Clomiphene Citrate plus N acetyl cystine

• Registration Number: NCT03241472
• Lead Sponsor: Assiut University

Brief Summary

Infertility is defined as a couple's inability to become pregnant after one year of unprotected intercourse in women 35 years old and younger, and for six months in women over age 35 years. In any given year, about 15 percent of couples in North America and Europe who are trying to conceive are infertile

Detailed Description

Not available

Study Timeline

• Study Start: 2016-02
• Primary Completion: 2017-05
• Study Completion: 2017-06
• Status Verified: 2017-08
• Study First Submitted: 2017-08-03
• Study First Submitted QC: 2017-08-03
• Last Update Submitted: 2017-08-03
• Study First Posted: 2017-08-07
• Last Update Posted: 2017-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• All primary and secondary. Infertility due to anovulation

Exclusion Criteria

• Male factor infertility, tubal factor.
• Endocrineopathy
• Hypothyrodism
• Morbid obesity
• Under weight
• Patient with previous surgery including drilling of ovary, Clomiphene Citrate resistant to ovulation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Lertozole	Letrozole	oral tablets 5 mg start from third day cycle for 5 days
clomiphene plus N- acetyl cystiene	Clomiphene Citrate plus N acetyl cystine	clomiphene 100 mg plus N-acetyl cystiene 600 mg start from third day cycle for 5 days

Primary Outcome Measures

Name	Time	Method
rate of ovulation	3 months	ultrasound evaluation