Reproductive Outcome in Assisted Conception Cycles

Not Applicable

Completed

• Conditions: Infertility
• Interventions: Diagnostic Test: follicular stimulating hormone; Diagnostic Test: Anti-mullerian hormone; Radiation: Basal antral follicle count

• Registration Number: NCT03846388
• Lead Sponsor: Assiut University

Brief Summary

Infertility is the failure to conceive after regular unprotected sexual intercourse for one year. Primary infertility refers woman who has never conceived, and secondary infertility to one who has had a previous pregnancy.The most frequent causes for infertility are ovulatory disorder or anovulation (27-30%) , tubal factor(20-22%), abnormal semen parameters(45-50%). Unexplained infertility refers to infertile couples in whom standard investigations, including tests of ovulation, tubal patency tests and semen analysis are normal. incidence 15-17% of infertile couples. New guidelines on infertility recommend that women with unexplained infertility should be advised for expectant management for 2 years .If pregnancy is not achieved after this period In vitro fertilization Should be considered. The Fast Track and Standard Treatment trial demonstrated A shorter time to pregnancy and higher per cycle pregnancy rates for In vitro fertilization compared with treatment with oral agents or gonadotropins in Patients with unexplained infertility. Successful pregnancy after assisted reproductive technology is influenced by numerous predictors that have been investigated in the previous years. The central predictors of success are the sperm, oocyte quality and endometrial receptivity. Oocyte quality depends mainly on the age of the woman , and her ovarian reserve. Parameters most commonly studied are the woman's age , her antral follicle count , and laboratory tests including serum randomly done during the menstrual cycle levels at day 3 of the cycle.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-02-01
• Study First Submitted: 2019-02-17
• Study First Submitted QC: 2019-02-18
• Study First Posted: 2019-02-19
• Primary Completion: 2022-01-31
• Study Completion: 2022-01-31
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-24
• Last Update Posted: 2023-07-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 292

Inclusion Criteria

• in vitro fertilization treatment due to many factors including tubal, male, and unexplained factors.
• body mass index (BMI) (18-35)kg/m2

Exclusion Criteria

1. patient age less than 20 and more than 40 years.
2. body mass index less than 18 and more than 35 kg/m2.
3. period of infertility less than 2 years..
4. untreated hyperthyroidism, hypothyroidism, diabetes, hypertension.

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patients with unexplained infertility	Anti-mullerian hormone	-
patients with tubal, male factor or polycystic ovary syndrome	follicular stimulating hormone	-
patients with tubal, male factor or polycystic ovary syndrome	Basal antral follicle count	-
Patients with unexplained infertility	Basal antral follicle count	-
Patients with unexplained infertility	follicular stimulating hormone	-
patients with tubal, male factor or polycystic ovary syndrome	Anti-mullerian hormone	-

Primary Outcome Measures

Name	Time	Method
live birth rate	12 months

Secondary Outcome Measures

Name	Time	Method
Number of fertilized oocytes	3 days

Trial Locations

Locations (1)

Assiut university; 🇪🇬 Assiut, Egypt