Nationwide Utilization of Danish Government Electronic Letter System for Increasing InFLUenza Vaccine Uptake
- Conditions
- Behavior and Behavior MechanismsInfluenza
- Interventions
- Behavioral: Behavioral Economic Principles
- Registration Number
- NCT05542004
- Lead Sponsor
- Tor Biering-Sørensen
- Brief Summary
In randomized clinical trials and observational studies, influenza vaccination has been shown to be effective in reducing influenza-related illness, hospitalizations, cardiovascular events, and mortality in select populations. However, the real-world effectiveness of influenza vaccination is limited by its uptake. This study will investigate investigate whether digital behavioral nudges delivered via the official, mandatory Danish electronic letter system can increase influenza vaccine uptake among eligible influenza vaccination candidates.
- Detailed Description
The study is a prospective, randomized, open-label implementation trial. The study population will consist of persons identified as eligible for free-of-charge influenza vaccination in the Danish health system aged 18 years and above. Subjects will be identified through Danish nationwide health registries using codes from the International Classification of Diseases, 10th revision (ICD-10) and the Anatomical Therapeutic Chemical (ATC) classification system. Individuals will be randomized to 1 of 10 arms (1 control arm and 9 intervention arms) with each testing different nudging strategies employing various behavioural economic principles. The interventions will be delivered through the official, mandatory Danish electronic letter system. All subject data will be retrieved from the Danish nationwide registries with the exception of information on intervention allocation. Endpoints will be retrieved at prespecified dates using prespecified search algorithms. The study will be performed in collaboration with the Danish Health Data Authority and Statens Serum Institut.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 964870
- Age >=65 years at January 15, 2023 (eligible for free influenza vaccination in the official Danish vaccination program)
- Access to the official, mandatory Danish electronic mailbox system
- Persons living in nursing homes
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Priming & Hot State Activation - 1 reminder Behavioral Economic Principles The standard letter sent out two times instead of once Collective Goal Behavioral Economic Principles Text added to the standard letter employing the specified behavioral economic principle Standard Letter Behavioral Economic Principles This group will receive a standard letter on the benefits of influenza vaccination without behavioral economic enhancement Depersonalized Letter Behavioral Economic Principles The standard letter without the recipient's name Gain-Framing/Context Behavioral Economic Principles Text added to the standard letter employing the specified behavioral economic principle Active Choice/Implementation Intention Prompt Behavioral Economic Principles Text added to the standard letter employing the specified behavioral economic principle Loss-Framing/Context Behavioral Economic Principles Text added to the standard letter employing the specified behavioral economic principle Cardiovascular Gain Frame Behavioral Economic Principles Text added to the standard letter employing the specified behavioral economic principle Expert Authority Behavioral Economic Principles Text added to the standard letter employing the specified behavioral economic principle
- Primary Outcome Measures
Name Time Method Number of participants who received an influenza vaccine Up to 3 months
- Secondary Outcome Measures
Name Time Method Time from intervention delivery to influenza vaccination Up to 3 months
Trial Locations
- Locations (1)
Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte
🇩🇰Hellerup, Hovedstaden, Denmark