Influence of Prism Adaptation on Spatial Neglect in the Early Versus Delayed Phase After Stroke: a Randomized, Placebo-controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Spatial Neglect After Stroke
- Sponsor
- University Ghent
- Enrollment
- 100
- Locations
- 3
- Primary Endpoint
- effect of prism adaptation
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
'Unilateral neglect' is a disorder that occurs regularly after stroke. It is caused by right- as well as left-sided brain lesions, but more often by right-sided lesions. Patients with this disorder neglect the contralesional side of space and/or their body. Their body axis is often shifted ipsilesionally. A specific disorder that can appear in neglect patients is 'contraversive pushing': a postural deviation to the neglected side because the patient pushes himself away from the ipsi- to the contralesional side.
One of the most promising neglect interventions is prism adaptation (PA): inducing an optical shift of the visual field by means of prism glasses. This results in a modulation of brain areas involved in neglect and in an improvement of the neglect symptoms and postural deviation.
Research questions:
- Which period is best suited to maximize therapeutic effects? In this respect the effects of early and delayed PA will be compared, regarding neglect-, postural and cerebral measures.
- Which factors lead to a less favorable treatment outcome or to therapy resistance for PA?
- Will the impact of PA be larger if postural factors are taken into account in the prism therapy?
Investigators
Eligibility Criteria
Inclusion Criteria
- •male or female
- •\> 17 years of age
- •stroke patients with clinical neglect, demonstrated by neglect tests
Exclusion Criteria
- •severe ocular abnormalities
- •not being able to perform prism adaptation or neglect tests
Outcomes
Primary Outcomes
effect of prism adaptation
Time Frame: Briefly after and 3 months after therapy cycle.
The effect of Prism Adaptation (PA) will be evaluated regarding the degree of neglect, postural control and cerebral functioning, briefly after the therapy cycle and 3 months later. Briefly after the PA sessions and three months later, in patients in the early as well as the delayed phase after stroke: * early: PA starting within 4 weeks after stroke; * delayed: PA starting 2 months after stroke; * OR divided in an early and a delayed group according to the median.
Secondary Outcomes
- The degree of well-being.(Briefly after and 3 months after therapy cycle.)