Neural Basis of Unilateral Spatial Neglect After Stroke: a Retrospective Disconnectome Based Study

University Hospital, Lille1 site in 1 country300 target enrollmentJune 1, 2011

ConditionsStroke

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Stroke
Sponsor: University Hospital, Lille
Enrollment: 300
Locations: 1
Primary Endpoint: Assessment of peripersonal Unilateral Neglect with the BEN (Batterie d'évaluation de la negligence, Battery of tests for the quantitative assessment of unilateral neglect)
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Retrospective cohort study of consecutive patients investigated in a neurorehabilitation ward after a first hemispheric stroke. Unilateral spatial Neglect (USN) and other cognitive impairments (including attention, executive functions, memory) have been assessed in routine care at the subacute phase (<6 months). MRI scans have also been done in routine care.

The study aims at linking lesion characteristics, disconnections induced and expression of the different modalities of USN

Registry

clinicaltrials.gov

Start Date

June 1, 2011

End Date

December 31, 2021

Last Updated

3 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University Hospital, Lille

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•First hemispheric adult stroke patient
•Non-opposed to inclusion
•Confirmed by MRI
•Assessment of cognitive functions during the subacute phase (3 weeks to 6 months after stroke onset

Exclusion Criteria

•History of previous stroke or neurological disorders
•Inability to perform cognitive assessment due to severe comprehension, cognitive or psychiatric disorder
•Uncorrected severe loss of visual acuity
•Contra-indications to MRI

Outcomes

Primary Outcomes

Assessment of peripersonal Unilateral Neglect with the BEN (Batterie d'évaluation de la negligence, Battery of tests for the quantitative assessment of unilateral neglect)

Time Frame: One assessment, during the subacute phase after stroke (3 weeks to 6 months)

Secondary Outcomes

Assessment of personal Unilateral Spatial Neglect with the Fluff Test(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Assessment of personal Unilateral Spatial Neglect with the Comb and Razor Test(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Assessment of Attention with the Test of Attentional Performance(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Assessment of Executive Functions with the Stroop Test(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Assessment of Executive Functions with the Trail Making Test(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Assessment of Executive Function with Verbal and Categorial Fluency test(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Assessment of verbal Memory with the verbal span task(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Gait assessment (Lindmark score)(3 months after stroke)
Assessment of visual Memory with the Doors test(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Assessment of visual Memory with the Rey figure test(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Assessment of Executive Functions with the test of commissions(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Assessment of verbal Memory with the Grober and Buschke Task(One assessment, during the subacute phase after stroke (3 weeks to 6 months))
Identification of brain lesions by Anatomical MRI (T1, FLAIR, T2*, Diffusion)(up to 6 months)
Postural assessment with the PASS(3 months after stroke)