Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Estimated Glomerula Filtration Rate
研究概览
简要总结
Critically ill patients are at risk of developing a sudden decrease of kidney function which may be detected by a decrease in urine output or is diagnosed on the basis of blood tests for substances normally eliminated by the kidney, primarily creatinine.
Because it takes about 24 hours for the creatinine level to rise, even if both kidneys have ceased to function, better markers are needed.
This trial is investigating if the marker urinary dickkopf-3 (uDKK3) allows an early prediction of a sudden decrease of kidney function.
详细描述
Urinary dickkopf-3 (uDKK3), a stress-induced renal tubular epithelium-derived glycoprotein, has been identified as a biomarker predicting persistent kidney dysfunction.
In this prospective observational trial in patients at high risk of developing acute kidney injury we will assess whether urinary dickkopf-3 serves as a predictor of acute kidney injury.
Patients of the intensive care units of Saarland University Hospital will be surveyed for up to two years after their admission to the intensive care unit.
The progression of the estimated Glomerular Filtration Rate and uDKK3 will be monitored.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients treated on the intensive care units of Saarland University Hospital.
排除标准
- •Patients on renal replacement treatment before admission to the intensive care unit.
- •Patients with chronic kidney disease stage CKD G3b or below.
- •Known kidney disease.
- •Kidney transplantation.
- •Intoxications leading to dialysis treatment.
- •Participation in other clinical trials.
结局指标
主要结局
Estimated Glomerula Filtration Rate
时间窗: Throughout observational period, defined as timeframe from admission to intensive care unit up to two years after.
Estimated Glomerula Filtration Rate by CKD-EPI-formula.
Urinary dickkopf-3
时间窗: Throughout observational period, defined as timeframe from admission to intensive care unit up to two years after.
Urinary dickkopf-3
次要结局
- Mortality(Throughout observational period, defined as timeframe from admission to intensive care unit up to two years after.)
- End Stage Renal Disease(Throughout observational period, defined as timeframe from admission to intensive care unit up to two years after.)
- Length of renal replacement therapy(During the ICU stay.)