Noise Enhanced Galvanic Vestibular Stimulation in Hemispatial Neglect
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- Measures of Hemispatial Neglect
研究概览
简要总结
The purpose of the current proposal is to pilot a new and potentially improved treatment for neglect. The procedure involves the delivery of transcutaneous small-amplitude current to the vestibular nerves that lie directly below the mastoid bones.
详细描述
The purpose of the current proposal is to pilot a new and potentially improved treatment for neglect. The procedure involves the delivery of transcutaneous small-amplitude current to the vestibular nerves that lie directly below the mastoid bones. With the intention of boosting activity in the damaged left hemisphere, positive and negative current is delivered to the left and right mastoids respectively. While successfully used to rehabilitate gait and balance disorders, the procedure has only once been applied to neglect.
In the present investigation, we will first confirm and then optimize the conditions under which galvanic vestibular stimulation (GVS) ameliorates neglect. This in turn will justify subsequent work (in a later funding cycle) that will demonstrate the safety and efficacy of the treatment on a much larger clinical scale, and merit the construction of a miniaturized portable device.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Device Feasibility
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All participants must be literate in English
- •Right handed
- •Have corrected near-visual acuity of 20/40 or better
- •Patients must also have a minimum of twelve years education
- •These inclusionary criteria are based on the data of both Black, Yu, Martin, and Szalai (90) and our own studies.
- •They are intended to assure that only patients with sufficiently severe symptoms will be admitted to our study.
排除标准
- •Exclusionary criteria include:
- •Homonymous hemianopia
- •Presence of a severe field cut extending toward the midline on formal perimetry (however many patients who have field cuts restricted to the periphery will be able to fully perceive our stimulus displays so can be included
- •Evidence of aphasia on clinical examination (crossed aphasia)
- •A significant history of other neurological or psychiatric illness or drug/alcohol abuse
研究组 & 干预措施
Parameter Determination
Testing potential effects of GVS on the symptoms of neglect
干预措施: Transcutaneous current to the vestibular nerve (Device)
结局指标
主要结局
Measures of Hemispatial Neglect
时间窗: 30 days
Improvement of Hemispatial neglect
次要结局
未报告次要终点