Combining Galvanic Vestibular Stimulation and Motor Training in Traumatic Brain Injury Survivors With Attentional Deficits
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- TBI
- Sponsor
- Spaulding Rehabilitation Hospital
- Enrollment
- 7
- Locations
- 1
- Primary Endpoint
- Sustained Attention to Response Task
- Status
- Terminated
- Last Updated
- 8 years ago
Overview
Brief Summary
The overall goal of the proposed project is to perform a preliminary study to assess the potential effects of galvanic vestibular stimulation (GVS) on the outcomes of a cognitive test of attention and the outcomes of robot-assisted upper-limb rehabilitation.
Detailed Description
We plan to explore the use of GVS on the severity of attention span deficits and motor training delivered using a spring-based robot. We intend to carry out the study in a small cohort of traumatic brain injury (TBI) survivors (20 subjects). Subjects with attention span deficits but no significant motor impairments will solely undergo a cognitive test of attention with/without GVS. Subjects with both attention span deficits and significant motor impairments will undergo a cognitive test of attention and robot-assisted upper-limb rehabilitation with/without GVS.
Investigators
Paolo Bonato
Director, Motion Analysis Lab
Spaulding Rehabilitation Hospital
Eligibility Criteria
Inclusion Criteria
- •Moderate to severe traumatic brain injury involving cognitive and/or motor deficits.
- •Neurological injury \>1 year prior to study enrollment
- •Significant attention deficit
- •For subjects with motor deficits (arms 2 and 3), sufficient voluntary movement and range of motion in the most-affected upper extremity to use the robotic arm system (Armeo Spring)
Exclusion Criteria
- •Pregnancy
- •History of seizures within 6 months of study enrollment
- •Major depression
- •Cognitive impairment that may interfere with understanding instructions
- •Severe limitations of upper extremity range of motion
- •Agitation
- •Other major neurological or psychiatric diseases
- •Participation in other forms of therapy/ intervention for upper extremity motor recovery
- •End-stage liver, kidney, cardiac or pulmonary disease
- •A terminal medical diagnosis with survival \<1 year
Outcomes
Primary Outcomes
Sustained Attention to Response Task
Time Frame: Baseline and end-of-treatment data (up to 2 weeks)
Subjects are presented with objects (one at the time) on a computer screen and are instructed to press a key on the keyboard according to the characteristics of the object shown on the computer screen. Error rates are measured as percentage of erroneous key selections.