The Effect of Vestibular Stimulation on Cerebral Blood Flow
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Healthy Volunteer
- Sponsor
- Duke University
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Changes in cerebral blood flow
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
This is a prospective, non-randomized study designed to generate preliminary data to assess the effect of a new portable non-invasive caloric stimulator on EEG waveform and cerebral blood flow on normal healthy volunteers.
Detailed Description
Study activities include monitoring with bilateral transcranial Doppler (TCD), EEG and continuous EKG monitoring at 30 second intervals for 5 minutes. This is followed by placement of the caloric stimulator investigational device for 20 minutes. An additional 20 minutes of TCD and EEG monitoring will also be recorded. This will end study participation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •no history of neurological disease
Exclusion Criteria
- •persons under the age of 18
- •pregnant or nursing women
- •history of neurological disease
- •history of psychiatric disease
- •congenital heart defect, known cardiac shunt
- •inner ear or pulmonary disease
Outcomes
Primary Outcomes
Changes in cerebral blood flow
Time Frame: 20 minutes
Changes in cerebral blood flow will be quantified through the use of bilateral transcranial Doppler (TCD). The baseline TCD of three vessels will be compared with measurements taken at 30 second intervals for 5 minutes after caloric stimulation.
Secondary Outcomes
- Alterations in EEG readings(40 minutes)
- Alterations in regional cerebral brain flow (rCBF)(40 minutes)