Effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with colorectal cancer

Phase 3

Conditions: Colorectal cancer.
Malignant neoplasm of colon, unspecified

Registration Number: IRCT20180306038979N1

Lead Sponsor: Ahvaz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 80

Inclusion Criteria

Patients with stage ?? or ??? colorectal cancer if they have to begin chemotherapy;
Aged 18 years or more;
BMI range of 18.5-30 kg/m2;
Serum 25(OH)D < 30 ng/ml;
Not having autoimmune disease, diabetes, hypertension, renal, hepatic, parathyroid, and gastrointestinal disorders;
No taking vitamin D and/or omeaga-3 supplements and other vitamin- mineral supplements or parenteral nutrition;
Not taking laxative, anti-inflammatory and blood thinner medications;
Absence of allergic to fish and fish products, and history of having other cancers.

Exclusion Criteria

Affecting by any acute disease during the study;
Changing the drug regimen; refusing to continue the chemotherapy;
Unwilling to continue the study;
Patients who had less than 90% compliance with treatment.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum level of TNF-a. Timepoint: Before and 8 weeks after intervention. Method of measurement: Serum TNF-a levels will be assessed by ELISA and Bender Med kit (Bender Med, Germany).

Secondary Outcome Measures

Name	Time	Method
Tumor marker CEA. Timepoint: Before and 8 weeks after intervention. Method of measurement: Tumor marker CEA will be assessed by ELISA and CanAg kit (CanAg, Italy).