Efficacy of Prednisolone on ICSI outcomes in a group of women with recurrent implantation failure
Phase 2
Recruiting
- Conditions
- Condition 1: unovulation female infertility. Condition 2: tubal female inferility. Condition 3: male factor female infertility. Condition 4: unspecified female infertility. Condition 5: complication of artificial fertilization.Female infertility associated with anovulationFemale infertility of tubal originFemale infertility associated with male factorsFemale infertility, unspecifiedComplication associated with artificial fertilization, unspecified
- Registration Number
- IRCT2016091618662N2
- Lead Sponsor
- Avicenna Infertility Clinic
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 220
Inclusion Criteria
Inclusion Criteria: 1- At least 2 unsuccessful IVF/ICSI cycles
2- Grade A or AB of transferred embryos in previous cycles and at least 6 embryos transferred
3- Age<40years 4- FSH<15
5- Sperm>10 milion counts, >3% normal morphology
Exclusion Criteria
1- Utilization of donation systems 2- Uncontrolled diseases such as Diabetes, HTN, Lupus, Renal failures,...
3- Abnormal Katyotype 4- Anatomical abnormalities( congenital, submucosal myoma, Asherman syn,...)
5- Endometriosis grade 3, 4
6- Women who had Endometrial scratch in the same cycle
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ICSI Outcome(chemical pregnancy). Timepoint: two weeks afert embryo transfer. Method of measurement: serum Beta HCG.;Clinical pregnancy. Timepoint: three weeks after embryo transfer. Method of measurement: transvaginal ultrasound.
- Secondary Outcome Measures
Name Time Method Oocyte quality. Timepoint: on the oocyte collection day. Method of measurement: morphologic assesment with microscope.;Embryo quality. Timepoint: 2 or 3 days after oocyte collection. Method of measurement: morphologic assesment with microscope.;Fertilization rate. Timepoint: 2 or 3 days after oocyte collection. Method of measurement: (embros number/injected oocytes numbers) * 100.;Prednisolone complications. Timepoint: any time of trial. Method of measurement: history and lab tests.