Clinical course and genetic characteristics for familial colorectal cancer and intestinal polyposis syndrome
Not Applicable
- Conditions
- Neoplasms
- Registration Number
- KCT0000673
- Lead Sponsor
- Yonsei University, Wonju Severance Christian Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 500
Inclusion Criteria
(1) Adult male and female less than the age of 70 over the twenty years old.
(2) The patients and their families satisfied the revised Bethesda guideline 2004 version
(3) patients and their families who diagnosed colorectal cancer with MSI positive or abnormal DNA repair protein or MMR gene mutation
(4) Patients and their families who diagnosed with FAP or FAP subtype
(5) Patients and their families who diagnosed with colon polyposis syndrome or polyposis syndrome suspect
(6) Agree to paticipate the clinical trial
Exclusion Criteria
(1) The medical condition that cannot perform the clinical trial
(2) Disagree to the clnical trial
(3) Patient who paticipate another clinical trial
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The clinical characteristic of familial colorectal cancer and intestinal polyposis syndrome;The genetic characteristic of familial colorectal cancer and intestinal polyposis syndrome
- Secondary Outcome Measures
Name Time Method Genetic test of MSI, MMR IHC(MLH1, MHS2, MSH6, PMS2) for familial colorectal cancer;Genetic test of APC, MYH, SKT11, SMAD/DPC4, PTEN for intestinal polyposis syndrome