Clinical course, outcome and genetics of inherited arrhythmias in childrenA multicenter study

Conditions: I49.8
I49
I47.2
I45.8
Other specified cardiac arrhythmias
Other cardiac arrhythmias
Ventricular tachycardia
Other specified conduction disorders

Registration Number: DRKS00028138

Lead Sponsor: Deutsches Herzzentrum München, Technische Universität München

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 796

Inclusion Criteria

Age between 0 and less than 18 years
- Clinical or genetic diagnosis of congenital arrhythmia syndrome
- Clinical or genetic diagnosis of a congenital disorder of the cardiac conduction system

Exclusion Criteria

- Presence of structural heart defect
- Age of initial diagnosis over 18 years

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Description of clinical course, molecular genetic etiologies, and outcome of children and adolescents with inherited arrhythmia disorders by collecting data about clinical course, imaging, and outcome.

Secondary Outcome Measures

Name	Time	Method
Identification of clinical risk factors for the occurrence of malignant cardiac arrhythmias and for sudden cardiac death / sudden cardiac death equivalent and genotype-phenotype correlation with regard to the course of the disease and the outcome of inherited arrhythmia syndromes in children and adolescents by collecting data on the occurrence of a severe arrhythmia ((non-)sustained ventricular tachycardia in the ECG, long-term ECG or stress test) or sudden cardiac death/equivalent to sudden cardiac death (survived sudden cardiac death, shock caused by ICD, ventricular tachycardia with hemodynamic instability) and result of molecular genetic diagnostics, affected gene and precise localization.