NCT00220246Unknown不适用
Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 130
- 试验地点
- 1
研究概览
简要总结
Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.
详细描述
Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.
研究设计
- 研究类型
- Observational
- 观察模型
- Defined Population
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 51 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Colorectal cancer before the age of 51 years
- •Microsatellite stable tumor
排除标准
- 未提供
研究者
研究点 (1)
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