Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer

• Conditions: Colorectal Neoplasms

• Registration Number: NCT00220246
• Lead Sponsor: Radboud University Medical Center

Brief Summary

Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.

Detailed Description

Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.

Study Timeline

• Study Start: 2004-03
• Study First Submitted: 2005-09-20
• Study First Submitted QC: 2005-09-20
• Study First Posted: 2005-09-22
• Status Verified: 2007-02
• Last Update Submitted: 2007-02-28
• Last Update Posted: 2007-03-01
• Study Completion: 2008-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

• Colorectal cancer before the age of 51 years

Microsatellite stable tumor

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Radboud University; 🇳🇱 Nijmegen, Netherlands