Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer

Radboud University Medical Center1 site in 1 country130 target enrollmentMarch 2004

ConditionsColorectal Neoplasms

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Colorectal Neoplasms
Sponsor: Radboud University Medical Center
Enrollment: 130
Locations: 1
Last Updated: 19 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.

Detailed Description

Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.

Registry

clinicaltrials.gov

Start Date

March 2004

End Date

September 2008

Last Updated

19 years ago

Study Type

Observational

Sex

All