Effects of Platelet-Rich Plasma and Ozone Therapy on Pain and Quality of Life in Knee Osteoarthritis: A Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Pain-Numerical Rating Scale
研究概览
简要总结
Knee osteoarthritis can frequently occur with advancing age. In cases of pain that persists despite hot/cold applications, drug therapy and exercise, intra-articular injections are considered. In advanced-stage gonarthrosis, steroid injections may respond. However, in mild and moderate knee arthritis, regenerative methods come to the forefront because the joint cartilage is still partially/completely intact. PRP and ozone therapy are frequently applied intra-articular treatments. This study will compare the effects of both injection methods on clinical outcomes.
详细描述
Knee osteoarthritis is a common arthrosis that can be encountered frequently with increasing life expectancy. In mild-moderate stages, hot/cold applications, drug treatments and exercise applications are usually applied, while in those who do not respond, physical therapy or intra-articular injection treatments are applied. This retrospective study aims to examine the effects of intra-articular Platelet Rich Plasma (PRP) and ozone therapy on pain, functionality and quality of life in patients with Stage 2-3 gonarthrosis according to the Kelgren-Lawrence (KL) Classification.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •30-70 years old, Stage 2-3 gonarthrosis according to KL
- •Voluntariness to participate in the study
排除标准
- •Cognitive dysfunction
- •General medical condition is not suitable for injections and evaluations
- •History of knee injections in the last 3 months
- •History of previous knee surgery
- •Bleeding disorders or those taking medications that may cause bleeding disorders after injections
结局指标
主要结局
Pain-Numerical Rating Scale
时间窗: From enrollment to the end of treatment at 3rd month
Pain level will be evaluated with the Numerical Rating Scale. (minimum: 0, maximum: 10)
次要结局
- Pain, stiffness and physical function-WOMAC(From enrollment to the end of treatment at 3rd month)
- Quality of life-SF-12(From enrollment to the end of treatment at 3rd month)
研究者
Selda Çiftci
Medical Doctor
Sisli Hamidiye Etfal Training and Research Hospital