LCCC 1213: Defining Molecular and Functional Imaging Correlates of Renal Cell Carcinoma Biological Features
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- Feasibility of FDG-PET-MRI making useful measurements that might be then used to globally assess tumor biological features
研究概览
简要总结
This pilot study is designed to evaluate imaging parameters indicative of underlying tumor biology. Patients with large renal masses (>3 cm, or at the discretion of the investigator) who are planning to undergo nephrectomy will be identified, and recruited to undergo a contrast-enhanced magnetic resonance-Fluorodeoxyglucose-positron emission tomography (MR-FDG-PET) scan.
详细描述
This pilot study is designed to evaluate imaging parameters indicative of underlying tumor biology. Patients with large renal masses (>3 cm, or at the discretion of the investigator) who are planning to undergo nephrectomy will be identified, and recruited to undergo a contrast-enhanced magnetic resonance-Fluorodeoxyglucose-positron emission tomography (MR-FDG-PET) scan. Samples collected from their tumor after it is removed will undergo a variety of laboratory tests, including biomarker assessments and genotyping. By examining primary renal masses via a combination of MR and FDG-PET functional imaging in concert with tissue based tests, areas of hypermetabolism and hypervascularization will be evaluated as features of HIF activation or tumor subtype.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 18 years of age (no upper age limit)
- •Informed consent obtained and signed
- •Clinically suspected RCC based on imaging performed prior to enrollment
- •Planned nephrectomy schedule that can accommodate a MR-FDG-PET scan within 4 weeks prior to surgery
- •Willing to undergo gadolinium enhanced MRI with simultaneous acquisition of FDG-PET uptake by the tumor within 4 weeks prior to nephrectomy
- •Willing to consent for genetic and proteomic analysis of tumor and germline nucleic acids
- •Women of childbearing potential must have a negative serum or urine pregnancy test performed within 7 days prior to FDG-PET-MRI
- •Breast feeding women cannot do so for 24 hours after FDG injection
- •Patient is willing to fast for 4 hours, including avoiding any sugar-containing drinks.
- •Patient is willing to drink at least 32 ounces of water (or other no-sugar-containing fluids) within 4 hours prior to arriving for scans.
排除标准
- •History of severe reaction to gadolinium-enhanced MRI
- •Poorly controlled diabetes mellitus
- •Inability to tolerate PET and/or MRI
- •Presence of pacemaker or intracranial aneurysm clip
- •GFR < 30mL/min as measured via Cockcroft-Gault equation
- •Inability to lie flat for >1 hour
- •Pregnant female
- •History of a prior malignancy within past 5 years are excluded unless they have been disease free for 3 or more years or unless they have a completely resected non-melanoma skin cancer, low risk prostate cancer, or other low risk tumor history at the discretion of the investigator.
- •Substance abuse, medical, psychological, or social conditions that may interfere with the patient's participation in the study
结局指标
主要结局
Feasibility of FDG-PET-MRI making useful measurements that might be then used to globally assess tumor biological features
时间窗: 4 weeks
This is a feasibility study. Feasibility will be determined by the quality of the FDG-PET-MRI measurements. That is, the measurements represent what the investigators hope they are measuring. With 10 of 10, the 100% rate has an exact 95% confidence interval of 69% to 100%. The interval width, representing a measure of precision, is 31%. The tumor biological features that will be assessed include genetic analyses performed for commonly mutated genes in kidney cancer (VHL, PBRM1, SETD2, HIF1, UTX, MLL2) and protein expression analyses performed on HIF1 and HIF2 protein expression using standard immunohistochemistry. These genetic and protein expression analyses will be performed on tissue samples collected within four weeks of imaging from tissue removed via nephrectomy.
次要结局
未报告次要终点