NCT05670275招募中不适用
Microecology and Host Immunity in Patients With Severe COVID-19 Infection
Chinese PLA General Hospital1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2022年12月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- death
研究概览
简要总结
The purpose of this study was to analyze the relationship between the microbial community, host immunity and the prognosis of patients with severe COVID-19.
详细描述
Methods: Bronchoalveolar lavage specimens of patients with severe COVID-19 were collected and studied to analyze the relationship between the composition of patients' microecology and the occurrence and development of disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Respiratory distress, respiratory rate ≥ 30 times/minute
- •At rest, oxygen saturation ≤ 93%
- •3）PaO2/FiO2 ≤300mmHg
- •Respiratory failure requires mechanical ventilation
- •Complicated with other organ failure requires ICU monitoring and treatment
- •Or in case of any of the following conditions, even if none of the above conditions is found, it is also managed as a critical case: ① pulmonary imaging shows that the lesion has significantly progressed more than 50% within 24-48 hours; ② Age>60 years old; ③ Complicated with serious chronic diseases (including diabetes, hypertension, coronary heart disease, malignant tumor, structural lung disease, pulmonary heart disease and immunosuppressed population)
排除标准
- •Pregnant women
- •Mental disorders
- •Patients with long-term mechanical ventilation for more than 60 days
- •Disagreement group researcher
结局指标
主要结局
death
时间窗: 28 day
mortality
次要结局
未报告次要终点
研究者
wang kaifei
Chinese PLA General Hospital
Chinese PLA General Hospital
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Microecology and Immunity in Patients With Anti-MDA5 Antibody Positive Dermatomyositis and Interstitial Lung DiseaseMicrobiomeImmune FunctionAnti-MDA5 Antibody Positive DermatomyositisNCT06203249Chinese PLA General Hospital50
招募中
不适用
The immune system and microbial tone in relation to NAFLD/NASH before and after BARIatric surgery in the morbidly obese in Amsterdam; the BARIA cohort study.obesityinsuline resistance100184241001796910019654NL-OMON50702Vasculaire Geneeskunde1,500
招募中
不适用
The immune system and microbial tone in relation to NAFLD/NASH before and after BARIatric surgery in the morbidly obese in Amsterdam; the BARIA cohort study.obesitynafld-nashbariatric surgeryNL-OMON22589amc1,500
已完成
不适用
The effect of antibiotics and the gut flora on the immune system.sepsis, gut flora depletion, systemic immune responseNL-OMON27808Academisch Medisch Centrum, Amsterdam12
招募中
不适用
Involvement of microflora in host immune responses after respiratory syncytial virus infectionsRSV infectious diseasesJPRN-UMIN000015983Chiba University10