Microecology and Host Immunity in Patients With Anti-melanoma Differentiation Associated Gene 5 Antibody Positive Dermatomyositis and Interstitial Lung Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The relationship between the microbial community and the presence or absence of interstitial lung disease
研究概览
简要总结
The purpose of this study was to analyze the relationship between the microbial community, host immunity and the presence or absence of concurrent rapidly progressive interstitial lung disease patients with anti-MDA5 antibody positive dermatomyositis.
详细描述
Methods: Bronchoalveolar lavage specimens of patients with anti-MDA5 antibody positive dermatomyositis and interstitial lung disease were collected and studied to analyze the relationship between the composition of patients' microecology and the occurrence and development of disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who meet the diagnostic criteria of dermatomyositis and anti-MDA 5 antibody positive.
- •Anti-MDA5 antibody positive DM patients with RPILD meet the diagnostic criteria for RPILD.
- •Must have undergone bronchoalveolar lavage.
- •Age≥18 years old.
- •Patients who signed informed consent forms
排除标准
- •Patients who had other connective tissue diseases.
- •Patients with ILD or RPILD caused by infection, tumors, drugs, biochemistry and other factors.
- •Pregnant or lactating patients.
- •The patient also participated in any other clinical trial.
- •Disagreement for inclusion in this study
结局指标
主要结局
The relationship between the microbial community and the presence or absence of interstitial lung disease
时间窗: 6 months
The relationship between the microbial community and the presence or absence of interstitial lung disease
次要结局
未报告次要终点
研究者
wang kaifei
Chinese PLA General Hospital
Chinese PLA General Hospital