Microecology and Host Immunity in Patients With Anti-melanoma Differentiation Associated Gene 5 Antibody Positive Dermatomyositis and Interstitial Lung Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- The relationship between the microbial community and the presence or absence of interstitial lung disease
Study Overview
Brief Summary
The purpose of this study was to analyze the relationship between the microbial community, host immunity and the presence or absence of concurrent rapidly progressive interstitial lung disease patients with anti-MDA5 antibody positive dermatomyositis.
Detailed Description
Methods: Bronchoalveolar lavage specimens of patients with anti-MDA5 antibody positive dermatomyositis and interstitial lung disease were collected and studied to analyze the relationship between the composition of patients' microecology and the occurrence and development of disease.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Other
Eligibility Criteria
- Ages
- 18 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients who meet the diagnostic criteria of dermatomyositis and anti-MDA 5 antibody positive.
- •Anti-MDA5 antibody positive DM patients with RPILD meet the diagnostic criteria for RPILD.
- •Must have undergone bronchoalveolar lavage.
- •Age≥18 years old.
- •Patients who signed informed consent forms
Exclusion Criteria
- •Patients who had other connective tissue diseases.
- •Patients with ILD or RPILD caused by infection, tumors, drugs, biochemistry and other factors.
- •Pregnant or lactating patients.
- •The patient also participated in any other clinical trial.
- •Disagreement for inclusion in this study
Outcomes
Primary Outcomes
The relationship between the microbial community and the presence or absence of interstitial lung disease
Time Frame: 6 months
The relationship between the microbial community and the presence or absence of interstitial lung disease
Secondary Outcomes
No secondary outcomes reported
Investigators
wang kaifei
Chinese PLA General Hospital
Chinese PLA General Hospital