Enhancing Rehabilitation in Aging Study (ERAS)
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 入组人数
- 38
- 主要终点
- Maximal Inspiratory Pressure
研究概览
简要总结
Acute Intermittent Hypoxia (AIH) is a rehab approach attributed to serotonin. AIH signaling also occurs via adenosine, and the pathways inhibit each other. Increased neural adenosine in aging may stymie AIH plasticity. The hypothesis is pre-treatment with adenosine 2A receptor inhibition (A2AI) enhances AIH effects on motor plasticity in unaffected adults. AIH exposures will be paired with A2AI or placebo, with a 4-week washout. Primary outcome measures include inspiratory and grip strength.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 40-79 years Non-smokers Ambulatory in the community Do not require assistance to complete activities of daily living
排除标准
- •Restrictive or obstructive lung conditions Pregnancy Active respiratory infections Use of antibiotics in the last 4 weeks Symptomatic cardiac disease BMI >35 kg/m2 Seizure disorder or progressive neurological condition Uses positive pressure mechanical ventilation when awake and upright, or oxygen assistance at any time
结局指标
主要结局
Maximal Inspiratory Pressure
时间窗: From enrollment to a 3-week follow-up.
Most negative pressure generated during a maximal inspiratory effort.
Maximal grip force
时间窗: From enrollment to a 3-week follow up.
Highest tension generated by the flexor muscles of the hand during a maximal grip.
次要结局
未报告次要终点