跳至主要内容
临床试验/CTRI/2025/10/095722
CTRI/2025/10/095722招募中不适用

Minimum effective volume of 0.5 percent Ropivacaine and 2 percent Lignocaine mixture for ultrasound guided Retroclavicular Brachial Plexus Block: A Prospective Dose Finding Study

AIIMS New Delhi1 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2025年10月18日最近更新:

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
25
试验地点
1
主要终点
The calculation of minimum effective volume (MEV50 and MEV95) of a mixture of 0.5% ropivacaine and 2% lignocaine for achieving a successful sensory and motor block at 30 minutes.

研究概览

简要总结

Combining faster onset lignocaine with other slower onset agents such as bupivacaine, levobupivacaine and ropivacaine can hasten the onset of the block. The minimum effective volume (MEV) and concentration of local anesthetics are key to maximizing the quality and safety of nerve blocks while minimizing risks such as local anesthetic systemic toxicity. Dose finding studies have been done using 0.5% bupivacaine and 0.5% ropivacaine in Retroclavicular Block (RCB). A clinically effective dose of combination of local anaesthetic (LA) for achieving an adequate block with retroclavicular approach is lacking. This study seeks to determine the MEV50 and MEV95 of a 3:2 mixture of 0.5% ropivacaine and 2% lignocaine in adults undergoing upper limb surgeries under the retroclavicular approach of infraclavicular block.

研究设计

研究类型
Interventional
分配方式
Na
盲法
Participant, Investigator and Outcome Assessor Blinded

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • ASA Physical Status I or II, Consent for regional anaesthesia and participation, Elective surgery of the upper limb, BMI between 18–30 kg/m².

排除标准

  • coagulopathy, allergy to local anaesthetics, pregnancy, pre existing neuropathy.

结局指标

主要结局

The calculation of minimum effective volume (MEV50 and MEV95) of a mixture of 0.5% ropivacaine and 2% lignocaine for achieving a successful sensory and motor block at 30 minutes.

时间窗: The calculation of minimum effective volume (MEV50 and MEV95) of a mixture of 0.5% ropivacaine and 2% lignocaine for achieving a successful sensory and motor block at 30 minutes.

次要结局

  • 1. Block performance time (time from the first insertion of the blocking needle to its removal)(2. Block onset time ( time required for a composite score of 14 points))

研究者

发起方
AIIMS New Delhi
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Heena Garg

AIIMS, New Delhi

研究点 (1)

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