Assessment of effects of iv lignocaine with IV OPOIDS vs IV opoid PLAIN over polytRauma stress response
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- effects of IV lignocaine combined with IV opioids compared to IV
研究概览
简要总结
This randomized prospective study evaluates the effect of IV lignocaine combined with IV opioids versus IV opioids alone on stress response in polytrauma patients. Conducted at GSVM Medical College, it measures biomarkers such as IL-6, LDH, serum lactate, D-dimer, and SOFA score to assess pain and inflammation. Patients are monitored over 36 hours to observe hemodynamic stability, toxicity, and analgesic efficacy, aiming to establish improved multimodal pain management protocols.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Age 18 to 85 years informed written consent A person who has suffered multiple traumatic injury in their body as a result of single event.
排除标准
- •Patient with relevant drug allergy Patient with opoid dependence Patients who refused to participate in studies.
结局指标
主要结局
effects of IV lignocaine combined with IV opioids compared to IV
时间窗: 0H HOURS, 8 HOURS ,24 HOURS, 36 HOURS
opioids alone on the physiological and biochemical stress (e.g., IL-6,
时间窗: 0H HOURS, 8 HOURS ,24 HOURS, 36 HOURS
LDH)response in polytrauma patients
时间窗: 0H HOURS, 8 HOURS ,24 HOURS, 36 HOURS
次要结局
- 1.Pain Control: Whether IV Lignocaine provides superior analgesia compared to opioid-only treatment.(2.Opioid Consumption: Whether IV Lignocaine reduces opioid requirements, thereby minimizing opioid-related side effects.)
研究者
Shivam Rai
GSVM Medical College Kanpur