Comparative study to evaluate the efficacy of dexmedetomidine via two routes i. e. intravenous and intrathecal in below knee surgeries under subarachnoid block

Completed

• Conditions: patients undergoing below knee orthopedic surgery

• Registration Number: CTRI/2017/08/009546
• Lead Sponsor: Dr Rajendra Prasad Government Medical College

Brief Summary

Present study is conducted on 90 patients, ASA I and II, aged between 20- 60 years, scheduled for below knee orthopedic surgery  under subarachnoid block. Patients were divided into two groups. Group I received 2.5 c.c. of 0.5% heavy bupivacaine plus 0.1 c.c. of normal saline ans 0.5 mic/ kg of dexmedetomidine in 100 ml of normal saline over 15 minutes given 20 minutes before subarachnoid block. Group II received 2.5 c.c. of 0.5% heavy bupivacaine plus 3 mic dexmedetomidine and 100 ml of normal saline over 15 minutes given 20 minutes before subarachnoid block. Duration of postoperative analgesia and rescue analgesia were compared between two groups. Two groups were also compared in terms of haemodynamic stability, onset of sensory and motor blockade and sedation.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07-05
• Study Completion: 2016-06-05
• Last Update Posted: 2017-08-24

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

ASA physical class I- II BMI 18.5<30.0 Patient undergoing below knee orthopaedic surgeries under subarachnoid block.

Exclusion Criteria

• Patients refusal for participation in the study.
• Uncontrolled and labile hypertension.
• Allergic to study drugs.
• Patients using alpha2- adrenergic receptors antagonists.
• Patients noted to have dysrhythmias on the electrocardiogram.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of postoperative analgesia and demand for rescue analgesia.	Time of subarachnoid block and demand for rescue analgesia over a period of 24 hours in post operative period

Secondary Outcome Measures

Name	Time	Method
Haemodynamic stability.	Onset and duration of sensory and motor block.

Trial Locations

Locations (1)

Dr Rajendra Prasad Government medical college, kangra at Tanda; 🇮🇳 Kangra, HIMACHAL PRADESH, India

Dr Rajendra Prasad Government medical college, kangra at Tanda

🇮🇳Kangra, HIMACHAL PRADESH, India

Isha Sharma

Principal investigator

9736391604

shshrm59@gmail.com