The Dynamics of Human Atrial Fibrillation

Completed

• Conditions: Atrial Fibrillation; Atrial Tachyarrhythmia

• Registration Number: NCT01008722
• Lead Sponsor: University of California, San Diego

Brief Summary

The study is conducted in patients with atrial fibrillation undergoing clinically prescribed ablation. The study hypothesis is that ablation at specific sites that are identified to 'drive' the atrial fibrillation may improve the success of the ablation procedure.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-11-05
• Study First Submitted QC: 2009-11-05
• Study First Posted: 2009-11-06
• Primary Completion: 2014-04
• Study Completion: 2014-05
• Status Verified: 2016-12
• Results First Submitted: 2016-12-12
• Results First Submitted QC: 2016-12-12
• Last Update Submitted: 2016-12-12
• Results First Posted: 2017-02-08
• Last Update Posted: 2017-02-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• Subjects will be patients undergoing electrophysiology study and ablation for paroxysmal or persistent atrial fibrillation (AF) after having failed >or= 1 anti-arrhythmic drug.

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Survival Free of Atrial Fibrillation	6 -12 months	Using data from cardiac implanted devices when possible, with recurrence defined as 1% recurrence, or data from intermittent 24-72 hour ambulatory ECGs, with recurrence defined as \>30 seconds.

Secondary Outcome Measures

Name	Time	Method
Termination or Slowing of Atrial Fibrillation During Ablation	acute	Using data from electrophysiological study, to determine termination of AF into sinus rhythm or organized atrial tachycardia. or slowing by 10% in cycle length measured on the coronary sinus.

Trial Locations

Locations (2)

University of California, San Diego; 🇺🇸 La Jolla, California, United States

VA San Diego Medical Center; 🇺🇸 San Diego, California, United States