The Study of Lithogenesis Processes in Patients With Non-alcoholic Fatty Liver Disease (NAFLD)

Completed

• Conditions: Urinary Lithiasis; NAFLD

• Registration Number: NCT06357052
• Lead Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Brief Summary

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, ranging from pure steatosis to non-alcoholic steatohepatitis and ultimately to liver cirrhosis. In order to study the association between NAFLD and nephrolithiasis while minimizing the confounding effect of metabolic syndrome, we investigated the impact of different degrees of NAFLD severity on potential risk factors for stone formation.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-07-19
• Primary Completion: 2022-04-30
• Study Completion: 2022-11-30
• Status Verified: 2024-04
• Study First Submitted: 2024-04-04
• Study First Submitted QC: 2024-04-04
• Last Update Submitted: 2024-04-04
• Study First Posted: 2024-04-10
• Last Update Posted: 2024-04-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• subject >= 18 years old
• able to sign the ICF
• Liver biopsy with report compatible with NAFLD

Exclusion Criteria

• alchol use > 20g/die
• other causes of liver disease
• active neoplasm

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the analysis of the correlation between the degree of severity of NAFLD And urinary lithogenic profilecharacterized by reduced urinary magnesium and altered urinary ammonium excretion.	15 years

Trial Locations

Locations (1)

Fondazione Policlinico A.Gemelli IRCCS; 🇮🇹 Roma, Italy