Expanded NIPT for Pregnancy Complications
Completed
- Conditions
- Preeclampsia SevereFetal Growth Restriction
- Registration Number
- NCT04311749
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
This study evaluates the utility of expanded panel non-invasive prenatal testing (NIPT) in detecting confined placental mosaicism of rare autosomal trisomies among pregnancies with placentally-mediated complications, including fetal growth restriction and severe preeclampsia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 70
Inclusion Criteria
- Diagnosis of early onset (< 34 weeks) severe fetal growth restriction, defined as estimated fetal weight less than 10th percentile with abnormal umbilical artery Dopplers OR estimated fetal weight less than 5th percentile alone OR biometric size at least 14 days behind expected dates
Exclusion Criteria
- Maternal age < 18 years
- Multifetal gestation
- Chronic hypertension require use of pharmacotherapy
- Tobacco or drug use
- Major congenital malformations
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Composite adverse pregnancy outcome Through study completion, an average of 2 years
- Secondary Outcome Measures
Name Time Method Preterm birth < 34 weeks Through study completion, an average of 2 years Neonatal intensive care unit admission Through study completion, an average of 2 years Intrauterine fetal demise Through study completion, an average of 2 years Death of fetus prior to delivery
Neonatal demise Through study completion, an average of 2 years Death of infant within 28 days of birth
Trial Locations
- Locations (1)
University of California, San Francisco
🇺🇸San Francisco, California, United States
University of California, San Francisco🇺🇸San Francisco, California, United States