NCT04311749已完成不适用
The Role of Expanded Panel Non-Invasive Prenatal Testing in Identifying Rare Autosomal Trisomies in Pregnancies With Placentally-Mediated Complications
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Composite adverse pregnancy outcome
研究概览
简要总结
This study evaluates the utility of expanded panel non-invasive prenatal testing (NIPT) in detecting confined placental mosaicism of rare autosomal trisomies among pregnancies with placentally-mediated complications, including fetal growth restriction and severe preeclampsia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of early onset (< 34 weeks) severe fetal growth restriction, defined as estimated fetal weight less than 10th percentile with abnormal umbilical artery Dopplers OR estimated fetal weight less than 5th percentile alone OR biometric size at least 14 days behind expected dates
排除标准
- •Maternal age < 18 years
- •Multifetal gestation
- •Chronic hypertension require use of pharmacotherapy
- •Tobacco or drug use
- •Major congenital malformations
结局指标
主要结局
Composite adverse pregnancy outcome
时间窗: Through study completion, an average of 2 years
次要结局
- Preterm birth < 34 weeks(Through study completion, an average of 2 years)
- Neonatal intensive care unit admission(Through study completion, an average of 2 years)
- Intrauterine fetal demise(Through study completion, an average of 2 years)
- Neonatal demise(Through study completion, an average of 2 years)
研究者
研究点 (1)
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