Comparative Study Between the Effect of Superficial Cryotherapy Using Dimethyl Ether and Propane Mixture and Microneedling in Treatment of Alopecia Areata
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Regrowth Scale
研究概览
简要总结
This study is randomized comparative analytical prospective study that included patients with mild and moderate alopecia areata. Patients was divided into two groups Patients in the first group underwent Superficial cryotherapy using dimethyl ether and propane (DMEP) at -57C (Cryotherapy group). Patients in the second group underwent Microneedling (Microneedling group). A total of six sessions were done at 2 weeks interval. Patients were followed-up for next 3 months to evaluate the persistence of hair regrowth after therapy. Patients were assessed at baseline and during follow up using photography, Dermoscopy, SALT score and regrowth scale.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 4 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ِAlopecia areata patients
排除标准
- •Alopecia totalis and universalis
- •ِAge less than four years.
- •ِPregnancy or breast-feeding.
- •ِActive infection at the site alopecia patch(s).
- •ِInflammation ate site of the alopecia patches
- •ِIntolerance to cold.
- •ِAssociated systemic illness such as thyroid, pernicious anaemia, diabetes mellitus, autoimmune connective tissue diseases.
- •ِPrevious treatment for alopecia areata over the last three months.
结局指标
主要结局
Regrowth Scale
时间窗: Change in regrowth scale from baseline to 3 months follow after end of sessions
0 score (regrowth \< 10%) no response 1. score (regrowth 11-25%) poor response 2. score (regrowth 26-50%) fair response 3. score (regrowth 51-75%) satisfactory response 4. score (regrowth ≥ 75%) excellent response.
次要结局
- SALT score(Change in salt score from baseline to 3 months follow after end of sessions)
研究者
Zeinab Abu elbaha Gouda
Assistant lecturer of Dermatology, Venereology and Andrology
Sohag University