Effect of circadian cortisol on postoperative IL-6(Interleukin-6), IL-8(Interleukin-8) and cortisol
- Conditions
- Not Applicable
- Registration Number
- KCT0002419
- Lead Sponsor
- Hallym University Medical Center- Chuncheon
- Brief Summary
Among 48 randomized patients, 44 completed the trial(mean[SD] age, 70.6[13.3]; 36[56.8%] women) and 4 patients dropped out(blood sample hemolysis, 2; change of surgery start time, 2). Each group have 22 patients. The cortisol at 24 and 48 hours after surgery differed between two groups. The duration of postoperative cortisol level above baseline was longer in the morning surgery. In IL-6, there were significant differences at 12, 24 and 48 hours after surgery. In IL-8, there were significant differences at 12 and 24 hours. Visual analogue scale had no significant difference.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 48
1) Patients scheduled for hip replacement or total hip arthroplasty
2) Men and women aged 20~100 years
3) American society of anesthesiology physical status 1~3
4) Body mass index(BMI) <30
1) Rejection of the patient
2) Sleep disorder
3) Psychiatric disorder
4) Taking psychiatric medication
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cortisol ;Interleukin-6(IL-6);Interleukin-8(IL-8)
- Secondary Outcome Measures
Name Time Method Visual analogue scale;The duration of postoperative cortisol level above baseline.