The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

Completed

• Conditions: Wound Healing; Glaucoma; Trabeculectomy
• Interventions: Procedure: Trabeculectomy

• Registration Number: NCT01115218
• Lead Sponsor: University of Cologne

Brief Summary

The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. The success rate of trabeculectomy with mitomycin C in the literature is about 75%. This leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term IOP reduction. Precisely this question is to be examined by the study.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-10
• Primary Completion: 2010-01
• Study First Submitted: 2010-05-03
• Study First Submitted QC: 2010-05-03
• Study First Posted: 2010-05-04
• Study Completion: 2012-03
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-16
• Last Update Posted: 2018-11-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• patients with glaucoma with a trabeculectomy required
• 60 eyes of 60 patients, The ratio of female / male is not involved.
• Eye pressure under local therapy: 20mmHg and above (corrected with pachymetry table).
• age of at least 18 years

Exclusion Criteria

• all patients not included in the group of inclusion criteria.
• less than 50yl anterior chamber fluid could be collected during the operation.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Glaucoma patients	Trabeculectomy	-

Trial Locations

Locations (1)

University Eye Hospital, University of Cologne; 🇩🇪 Cologne, NRW, Germany