Investigating Motor Cortex Processing for Pain Modulation
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Motor Activity
- Sponsor
- Spaulding Rehabilitation Hospital
- Enrollment
- 115
- Locations
- 1
- Primary Endpoint
- Change in Motor Cortex Excitability MEP Amplitude
- Status
- Terminated
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to investigate the effects of different types of interventions (motor learning, somatosensory learning, observation task, mental imagery and tDCS) on the perception of pain and motor cortex excitability in healthy male subjects. This is an exploratory study of healthy subjects only.
Detailed Description
There are 5 experiments: Exp1: motor learning (3 groups, crossover) - motor leaning with and without visual feedback and a control group. Exp2: sensory learning (4 groups, parallel) - sensory learning with and without feedback, an simple activation task and a control group. Exp3: observational task (2 groups, parallel) - an motor observational task and a control group. Exp4: mental imagery (2 groups, parallel) - a motor mental imagery and a control group. Exp5: tDCS over the motor cortex (2 groups, crossover) - active and sham tDCS. Note that this study has never been completed.
Investigators
Felipe Fregni
Principal Investigator
Spaulding Rehabilitation Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change in Motor Cortex Excitability MEP Amplitude
Time Frame: after each intervention
We aim to assess the effects of the intervention (ML, SL, OT and MI) on motor cortex excitability as measured by the change in motor evoked potential (using transcranial magnetic stimulation) before and after the given intervention. * For ML: MEP will be measured before and after each ML sessions in the same subject (crossover design - ML sighted/MLblind/ML control). * For SL: MEP will be measured before and after the treatment session in the each groups (parallel design - 1 session per group). * For OT: MEP will be measured before and after the treatment session in the each groups (parallel - 1 session per group). * For MI: MEP will be measured before and after the treatment session in the each groups (parallel design - 1 session per group).