Investigating Motor Cortex Processing for Pain Modulation

Phase 1

Terminated

• Conditions: Motor Activity

• Registration Number: NCT01404039
• Lead Sponsor: Spaulding Rehabilitation Hospital

Brief Summary

The purpose of this study is to investigate the effects of different types of interventions (motor learning, somatosensory learning, observation task, mental imagery and tDCS) on the perception of pain and motor cortex excitability in healthy male subjects. This is an exploratory study of healthy subjects only.

Detailed Description

There are 5 experiments:

Exp1: motor learning (3 groups, crossover) - motor leaning with and without visual feedback and a control group.

Exp2: sensory learning (4 groups, parallel) - sensory learning with and without feedback, an simple activation task and a control group.

Exp3: observational task (2 groups, parallel) - an motor observational task and a control group.

Exp4: mental imagery (2 groups, parallel) - a motor mental imagery and a control group.

Exp5: tDCS over the motor cortex (2 groups, crossover) - active and sham tDCS. Note that this study has never been completed.

Study Timeline

• Study Start: 2010-09
• Study First Submitted: 2011-06-29
• Study First Submitted QC: 2011-07-26
• Study First Posted: 2011-07-27
• Primary Completion: 2014-04
• Study Completion: 2014-04
• Results First Submitted: 2015-04-07
• Results First Submitted QC: 2017-03-14
• Results First Posted: 2017-03-16
• Status Verified: 2020-04
• Last Update Submitted: 2020-04-22
• Last Update Posted: 2020-04-24

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Male
• Target Recruitment: 115

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in Motor Cortex Excitability MEP Amplitude	after each intervention	We aim to assess the effects of the intervention (ML, SL, OT and MI) on motor cortex excitability as measured by the change in motor evoked potential (using transcranial magnetic stimulation) before and after the given intervention.; * For ML: MEP will be measured before and after each ML sessions in the same subject (crossover design - ML sighted/MLblind/ML control).; * For SL: MEP will be measured before and after the treatment session in the each groups (parallel design - 1 session per group).; * For OT: MEP will be measured before and after the treatment session in the each groups (parallel - 1 session per group).; * For MI: MEP will be measured before and after the treatment session in the each groups (parallel design - 1 session per group).

Trial Locations

Locations (1)

Spaulding Rehabilitation Hospital; 🇺🇸 Boston, Massachusetts, United States