Central Venous Pressure (CVP) Changes do Not Predict Preload Unresponsiveness
试验速览
- 阶段
- 不适用
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- the predictive value of changes in CVP to determine preload responsiveness
研究概览
简要总结
Passive leg raising (PLR) is routinely used to predict preload responsiveness in critically ill patients. However, real-time measurements of cardiac output are required to assess its effects. Some authors have suggested that in fluid non-responders, central venous pressure (CVP) increased markedly. By analogy with the CVP rules proposed by Weill et al to assess a fluid challenge, it has been hypothesized that an increase in CVP ≥ 5 mmHg during PLR can predict preload unresponsiveness.
Objective Investigation of whether an increase in CVP ≥ 5 mmHg during PLR predict preload unresponsiveness diagnosed by the absence of increase in velocity-time integral (VTI) of the flow in the left ventricular outflow tract by more than 10% (4).
Methods Critically ill patients with a central venous catheter in place and for whom the physician decided to test preload responsiveness by PLR were prospectively included. Transthoracic echocardiography was performed to obtain VTI. The CVP and VTI were measured before and during PLR.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients presenting with shock or other signs of circulatory failure (tachycardia, oliguria)
- •Need for the physician to test preload responsiveness
- •Patients already equipped by a central venous catheter for the measurement of CVP
排除标准
- •patients<18 years old
- •pregnancy
- •instaility justifying rapid increase in cathecolamines
结局指标
主要结局
the predictive value of changes in CVP to determine preload responsiveness
时间窗: ONE MINUTE TEST
Systolic, diastolic and mean arterial pressure will be assessed before and after the PLR test
次要结局
未报告次要终点
研究者
Hamzaoui Olfa
principal investigator
Hopital Antoine Beclere